The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

Osteoimmunology is a new subject which focuses on the communication between the
immune and the skeletal systems. Both the immune system and bone communicate with …

Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …

Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical
efficacy in rheumatoid arthritis and other inflammatory disorders; however, the precise …

Proinflammatory cytokines are major mediators in the pathogenesis of diseases of joints
such as rheumatoid arthritis and osteoarthritis. This review emphasizes that proinflammatory …

Bone resorption by osteoclasts and bone formation by osteoblasts are tightly coupled
processes implicating factors in TNF, bone morphogenetic protein, and Wnt families. In …

Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

Aims To compare gingival crevicular fluid (GCF) cytokines/chemokines levels between
periodontally healthy subjects and subjects diagnosed with chronic periodontitis (C h P) …