Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …

Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

High dietary fructose is a major contributor to insulin resistance and metabolic syndrome,
disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …