Visualization of double stranded DNA in gels with the binding of the fluorescent dye
ethidium bromide has been a basic experimental technique in any molecular biology …

Chemo-mechanical deformation of structured DNA assemblies driven by DNA-binding
ligands has offered promising avenues for biological and therapeutic applications. However …

Understanding the dynamic interactions of ligands to DNA is important in DNA-based
nanotechnologies. By structurally tracking the dissociation of Hoechst 33258-bound DNA (d …

There are certain small molecules that exhibit extraordinarily diverse biological activities.
Metformin is one of them. It is widely used as an antidiabetic drug for type-two diabetes …

A new Cu-based anticancer metallodrug which targets the translocator protein is
reported.[CuBr2 (TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug …

RNA functions are intrinsically tied to folding kinetics. The most elementary step in RNA
folding is the closing and opening of a base pair. Understanding this elementary rate …

The induced fit binding model describes a conformational change occurring when a small
molecule binds to its biomacromolecular target. The result is enhanced noncovalent …

Changes in the structural dynamics of double stranded (ds) DNA upon ligand binding have
been linked to the mechanism of allostery without conformational change, but direct …

Elucidating the role of quantum coherences in energy migration within biological and
artificial multichromophoric antenna systems is the subject of an intense debate. It is also a …

Most of the anticancer drugs bind to double-stranded DNA (dsDNA) by intercalative-binding
mode. Although experimental studies have become available recently, a molecular-level …