New insights into genome folding by loop extrusion from inducible degron technologies
Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …
wire distant loci together for gene regulation. These loops are continuously created …
A decade of 3C technologies: insights into nuclear organization
Over the past 10 years, the development of chromosome conformation capture (3C)
technology and the subsequent genomic variants thereof have enabled the analysis of …
technology and the subsequent genomic variants thereof have enabled the analysis of …
[HTML][HTML] Functional and mechanistic diversity of distal transcription enhancers
M Bulger, M Groudine - Cell, 2011 - cell.com
Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …
Metazoan promoters: emerging characteristics and insights into transcriptional regulation
Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …
elements, sequence motifs, the choice of transcription start sites and other features. Several …
[图书][B] Evolution: a view from the 21st century
JA Shapiro - 2011 - books.google.com
James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …
Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
Nuclear organization has been implicated in regulating gene activity. Recently, large
developmentally regulated regions of the genome dynamically associated with the nuclear …
developmentally regulated regions of the genome dynamically associated with the nuclear …
Transcription factories: genome organization and gene regulation
A Papantonis, PR Cook - Chemical reviews, 2013 - ACS Publications
All eukaryotic cells contain four RNA polymerases originally defined by their sensitivity to
different drugs, and now by the sets of genes they transcribe. 1− 4 Polymerase I produces …
different drugs, and now by the sets of genes they transcribe. 1− 4 Polymerase I produces …
[HTML][HTML] Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor …
The simultaneous measurement of three-dimensional (3D) genome structure and gene
expression of individual cells is critical for understanding a genome's structure–function …
expression of individual cells is critical for understanding a genome's structure–function …
An overview of methods for reconstructing 3-D chromosome and genome structures from Hi-C data
O Oluwadare, M Highsmith, J Cheng - Biological procedures online, 2019 - Springer
Over the past decade, methods for predicting three-dimensional (3-D) chromosome and
genome structures have proliferated. This has been primarily due to the development of high …
genome structures have proliferated. This has been primarily due to the development of high …
Interchromosomal interactions: a genomic love story of kissing chromosomes
Nuclei require a precise three-and four-dimensional organization of DNA to establish cell-
specific gene-expression programs. Underscoring the importance of DNA topology …
specific gene-expression programs. Underscoring the importance of DNA topology …