TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or
senescence is often triggered after mitotic exit. To characterize this process, we conducted …

Cancer arises through a complex interplay between genetic, behavioral, metabolic, and
environmental factors that combined trigger cellular changes that over time promote …

The centrosome influences the shape, orientation and activity of the microtubule
cytoskeleton. The pericentriolar material (PCM), determines this functionality by providing a …

Defective centrosome duplication is implicated in microcephaly and primordial dwarfism as
well as various ciliopathies and cancers. Yet, how the centrosome biogenesis is regulated …