The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

Hepatocellular carcinoma (HCC) is one of the most common and lethal types of cancer. This
study aimed to identify the expression regulatory network and a prognostic signature of …

In eukaryotes, the spindle assembly checkpoint protects genome stability in mitosis by
preventing chromosome segregation until incorrect microtubule-kinetochore attachment …

In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …

Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised
functions in mitosis are incompletely understood. Using degron tags for rapid inducible …

Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it
inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through …

Cyclin B: CDK 1 is the master kinase regulator of mitosis. We show here that, in addition to
its kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to …

UHRF1 is an epigenetic coordinator bridging DNA methylation and histone modifications.
Additionally, UHRF1 regulates DNA replication and cell cycle, and its deletion induces G1/S …

How the cell rapidly and completely reorganizes its architecture when it divides is a problem
that has fascinated researchers for almost 150 yr. We now know that the core regulatory …