Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Abstract As coronavirus disease 2019 (COVID-19) and aging are both accompanied by
cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures …

Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …

The global burden of neurodegenerative diseases underscores the urgent need for
innovative strategies to define new drug targets and disease-modifying factors. The …

The aging brain is shaped by many structural and functional alterations. Recent cross-
disciplinary efforts have uncovered powerful and integrated adaptive mechanisms that …