Cultured meat is an emerging biotechnology that aims to produce meat from animal cell
culture, rather than from the raising and slaughtering of livestock, on environmental and …

Rejuvenation of cells by reprogramming toward the pluripotent state raises increasing
attention. In fact, generation of induced pluripotent stem cells (iPSCs) completely reverses …

DNA methylation is a fundamental epigenetic mark that governs gene expression and
chromatin organization, thus providing a window into cellular identity and developmental …

Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of
hematological malignancies. Manufacturing of these cellular products includes culture …

Recreating human tissues and organs in the petri dish to establish models as tools in
biomedical sciences has gained momentum. These models can provide insight into …

Background Epigenetic marks are encoded by DNA methylation and accumulate errors as
organisms age. This drift correlates with lifespan, but the biology of how this occurs is still …

Recent studies have revealed the vital role of MSCs in bone regeneration. In both self-
healing bone regeneration processes and biomaterial-induced healing of bone defects …

Background Promoter hypermethylation of tumour suppressor genes is frequently observed
during the malignant transformation of colorectal cancer (CRC). However, whether this …

Epigenetic variations are inherited or uninherited effects that occur beyond the DNA
sequence of an individual. However, DNA sequence has a critical role in shaping epigenetic …

DNA methylation is a fundamental epigenetic mark that governs chromatin organization, cell
identity, and gene expression. Here we describe a human methylome atlas, based on deep …