Pathobiology of airway remodeling in asthma: the emerging role of integrins

C Joseph, AL Tatler - Journal of Asthma and Allergy, 2022 - Taylor & Francis
Airway remodeling is a complex clinical feature of asthma that involves long-term disruption
and modification of airway architecture, which contributes significantly to airway …

A dynamical model of TGF-β activation in asthmatic airways

HJ Pybus, RD O'dea, BS Brook - … and Biology: A Journal of the …, 2023 - academic.oup.com
Excessive activation of the regulatory cytokine transforming growth factor (TGF-) via
contraction of airway smooth muscle (ASM) is associated with the development of asthma. In …

The role of mathematical models in designing mechanopharmacological therapies for asthma

L Irons, BS Brook - Frontiers in Systems Biology, 2022 - frontiersin.org
Healthy lung function depends on a complex system of interactions which regulate the
mechanical and biochemical environment of individual cells to the whole organ …