During the last 50 years, the serotonergic (5-HT) system was reported to exert a complex
modulation of locomotor activity. Here, we focus on two key factors that likely contribute to …

Abstract Chx10-expressing V2a (Chx10+ V2a) spinal interneurons play a large role in the
excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the …

In mice, most studies of the organization of the spinal central pattern generator (CPG) for
locomotion, and its component neuron classes, have been performed on neonatal [postnatal …

Drug addiction is a brain disorder characterized by chronic, compulsive use of drugs.
Previous studies have found a number of chronic morphine-induced changes in the brain at …

Serotoninergic (5-HT) neurons are powerful modulators of spinal locomotor circuits. Most
studies on 5-HT modulation focused on the effect of exogenous 5-HT and these studies …

Chx10 阳性特异性标记的V2a 中间神经元(Chx10+ V2a) 在脊髓运动神经元(MN)
的兴奋性驱动中发挥重要作用. 目前已有研究通过化学遗传消融方法证实Chx10+ V2a …

Dopamine is well known to regulate movement through the differential control of direct and
indirect pathways in the striatum that express D1 and D2 receptors respectively. The spinal …

Hindlimb locomotion or walking is a highly stereotypical and coordinated activity that is
characterized by alternation in flexor and extensor muscles on the same side of the body …

Facilitating plasticity after spinal cord injury tends to be the focus of most modern
interventions for this condition. In particular, stem cell therapies attempt to both modulate …