[HTML][HTML] Challenges of drug-resistant malaria
Over the past six decades, the drug resistance of Plasmodium falciparum has become an
issue of utmost concern. Despite the remarkable progress that has been made in recent …
issue of utmost concern. Despite the remarkable progress that has been made in recent …
Antimalarial peptides: the long and the short of it
A Bell - Current Pharmaceutical Design, 2011 - ingentaconnect.com
Antimicrobial peptides include a diverse array of both natural and synthetic molecules
varying greatly in size, charge, hydrophobicity and secondary-structural features. Although …
varying greatly in size, charge, hydrophobicity and secondary-structural features. Although …
iAMAP-SCM: a novel computational tool for large-scale identification of antimalarial peptides using estimated propensity scores of dipeptides
Antimalarial peptides (AMAPs) varying in length, amino acid composition, charge,
conformational structure, hydrophobicity, and amphipathicity reflect their diversity in …
conformational structure, hydrophobicity, and amphipathicity reflect their diversity in …
In vitro and in vivo antimalarial activity of LZ1, a peptide derived from snake cathelicidin
Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides
(AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived …
(AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived …
Antiproliferative and antiplasmodial compounds from selected Streptomyces species
LH Rakotondraibe, R Rasolomampianina… - Bioorganic & medicinal …, 2015 - Elsevier
In continuation of our ongoing search for bioactive compounds from microbial extracts, we
performed antiproliferative and/or antimalarial assays on extracts of 806 microbial species …
performed antiproliferative and/or antimalarial assays on extracts of 806 microbial species …
Linear and cyclic dipeptides with antimalarial activity
L Pérez-Picaso, HF Olivo, R Argotte-Ramos… - Bioorganic & medicinal …, 2012 - Elsevier
Several natural and synthetic polypeptides possess important antimalarial activity. Shorter
peptides with potent antimalarial activity have also been described, among them linear di …
peptides with potent antimalarial activity have also been described, among them linear di …
New linear antiplasmodial peptides related to angiotensin II
Background Antiplasmodial activities of angiotensin II and its analogues have been
extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite …
extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite …
Systematic review: insight into antimalarial peptide
Antimalarial peptides varying in size, sequence, charge, conformation and structure,
hydrophobicity and amphipathicity reflect their heterogeneity in antimalarial activity. Due to …
hydrophobicity and amphipathicity reflect their heterogeneity in antimalarial activity. Due to …
Effects of the angiotensin II Ala-scan analogs in erythrocytic cycle of Plasmodium falciparum (in vitro) and Plasmodium gallinaceum (ex vivo)
The anti-plasmodium activity of angiotensin II and its analogs have been described in
different plasmodium species. Here we synthesized angiotensin II Ala-scan analogs to verify …
different plasmodium species. Here we synthesized angiotensin II Ala-scan analogs to verify …
Antiplasmodial activity of short peptide-based compounds
Three series of short peptide-based compounds were synthesized, which upon evaluation
against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium …
against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium …