The vascular basement membrane in the healthy and pathological brain

MS Thomsen, LJ Routhe… - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …

MSCRAMM-mediated adherence of microorganisms to host tissues

JM Patti, BL Allen, MJ McGavin, M Hook - Annual review of …, 1994 - go.gale.com
Microbial surface components recognizing adhesive matrix molecules (MSCRAMMs)
comprise a group of cell surface adhesins that bind specifically to the extracellular matrix …

Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

KM Baeten, K Akassoglou - Developmental neurobiology, 2011 - Wiley Online Library
The blood–brain barrier (BBB) is formed primarily to protect the brain microenvironment from
the influx of plasma components, which may disturb neuronal functions. The BBB is a …

[HTML][HTML] Fibrinolysis and COVID‐19: a plasmin paradox

RL Medcalf, CB Keragala, PS Myles - Journal of Thrombosis and …, 2020 - Elsevier
The COVID‐19 pandemic has provided many challenges in the field of thrombosis and
hemostasis. Among these is a novel form of coagulopathy that includes exceptionally high …

[PDF][PDF] Tumor invasion and metastases: role ofextracellular matrix. Rhoads Memorial Award Lecture

LA Liotta - Cancer res, 1986 - academia.edu
Metastasis is the major cause of morbidity and death for cancer patients. Treatment
modalities such as surgery, chemo therapy, and radiotherapy can now cure approximately …

[HTML][HTML] TGF-β and fibrosis

MH Branton, JB Kopp - Microbes and infection, 1999 - Elsevier
Transforming growth factor-beta (TGF-β) isoforms are multifunctional cytokines that play a
central role in wound healing and in tissue repair. TGF-β is found in all tissues, but is …

Plasminogen activators, tissue degradation, and cancer

K Danø, PA Andreasen, J Grøndahl-Hansen… - Advances in cancer …, 1985 - Elsevier
Publisher Summary This chapter discusses the role of plasminogen activators in various
biological processes. In specific, it describes two types of plasminogen activators—namely …

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

JR Clapper, MD Hendricks, G Gu… - American Journal …, 2013 - journals.physiology.org
Shortcomings of previously reported preclinical models of nonalcoholic steatohepatitis
(NASH) include inadequate methods used to induce disease and assess liver pathology …

Plasmin and plasminogen system in the tumor microenvironment: implications for cancer diagnosis, prognosis, and therapy

AG Bharadwaj, RW Holloway, VA Miller, DM Waisman - Cancers, 2021 - mdpi.com
Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

Arterial thrombus formation in cardiovascular disease

G Lippi, M Franchini, G Targher - Nature Reviews Cardiology, 2011 - nature.com
The pathogenesis of arterial thrombosis is complex and dynamic. Unlike venous thrombi,
arterial thrombi typically form under conditions of high blood flow and are mainly composed …