The vitamin D metabolite 1α, 25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the
transcription factor vitamin D receptor (VDR). In many tissues and cell types, VDR binds in a …

The classical function of Vitamin D, which involves mineral balance and skeletal
maintenance, has been known for many years. With the discovery of vitamin D receptors in …

Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It
plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display …

Immunomodulatory responses to the active form of vitamin D (1, 25-dihydroxyvitamin D, 1,
25D) have been recognized for many years, but it is only in the last 5 years that the potential …

The hormonal form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is an
immune system modulator and induces expression of the TLR coreceptor CD14. 1, 25 (OH) …

Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role
in various human cancers. Preclinical research indicates that the active metabolite of vitamin …

The population-based association between low vitamin D status and increased cancer risk
can be inconsistent, but it is now generally accepted. These relationships link low serum …

1α, 25-Dihydroxyvitamin D3 [1, 25-(OH) 2D3], the active metabolite of vitamin D3, is known
for the maintenance of mineral homeostasis and normal skeletal architecture. However …

Vitamin D deficiency has been linked to many human diseases such as Alzheimer's disease
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …

Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule.
Due to the general awareness of its importance for the overall well-being, vitamin D …