Breast cancer is the most frequent malignancy diagnosed in women. Approximately 70% of
breast tumors express the estrogen receptor (ER). Tamoxifen and aromatase inhibitors (AIs) …

Hypoxia is one of the fundamental biological phenomena that are intricately associated with
the development and aggressiveness of a variety of solid tumors. Hypoxia-inducible factors …

Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)‐positive
breast cancer. However, many patients still develop resistance to tamoxifen in association …

Tumor cells metastasize to distant organs through genetic and epigenetic alterations,
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …

Rationale: The adult heart is composed primarily of terminally differentiated, mature
cardiomyocytes that express signature genes related to contraction. In response to …

Butyrate is one of the short chain fatty acids, produced by the gut microbiota during
anaerobic fermentation of dietary fibres. It has been shown that it can inhibit tumor …

Background: Recently, microRNAs in cancer development have attracted much attention,
but their roles in tumorigenesis are still largely unknown. In this study, a functional role of …

Ductal carcinoma in situ (DCIS) is a noninvasive precursor lesion to invasive breast
carcinoma. We still have no understanding on why only some DCIS lesions evolve to …

Autophagy has become one of the most important mechanisms of chemotherapy resistance
by supporting the survival of tumor cells under metabolic and therapeutic stress. Here, we …

Breast cancer is the most common cancer in women for which the metastatic process is still
poorly understood. CD147 is upregulated in breast cancer and has been associated with …