Flavonoids against the Warburg phenotype—Concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

M Samec, A Liskova, L Koklesova, SM Samuel, K Zhai… - Epma Journal, 2020 - Springer
The Warburg effect is characterised by increased glucose uptake and lactate secretion in
cancer cells resulting from metabolic transformation in tumour tissue. The corresponding …

Quercetin: a natural compound for ovarian cancer treatment

R Shafabakhsh, Z Asemi - Journal of ovarian research, 2019 - Springer
Ovarian cancer is the main cause of death among all reproductive cancers in females. In
2018, ovarian cancer was the seventh most common cancer of women entire the world. A …

Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities

NGM Attallah, SA El-Sherbeni, AH El-Kadem… - Molecules, 2022 - mdpi.com
The acute inflammation process is explained by numerous hypotheses, including oxidative
stress, enzyme stimulation, and the generation of pro-inflammatory cytokines. The anti …

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

D Szczuka, A Nowak, M Zakłos-Szyda, E Kochan… - Nutrients, 2019 - mdpi.com
Panax quinquefolium L.(American Ginseng, AG) is an herb characteristic for regions of North
America and Asia. Due to its beneficial properties it has been extensively investigated for …

Role of Fisetin in Selected Malignant Neoplasms in Women

A Markowska, M Antoszczak, K Kacprzak, J Markowska… - Nutrients, 2023 - mdpi.com
A promising therapeutic window and cost-effectiveness are just two of the potential
advantages of using naturally derived drugs. Fisetin (3, 3′, 4′, 7-tetrahydroxyflavone) is a …

Modulation of Myb‐induced NF‐kB‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors

M Tian, D Tian, X Qiao, J Li… - Journal of cellular …, 2019 - Wiley Online Library
Abstract c‐Myb regulates tumorigenesis in multiple cancers. Here we show, for the first time,
the mechanism of c‐Myb‐mediated proliferation, invasion, and drug resistance in ovarian …

The use of natural compounds for the targeting and chemoprevention of ovarian cancer

F Pistollato, RC Iglesias, R Ruiz, S Aparicio, J Crespo… - Cancer Letters, 2017 - Elsevier
Among gynaecological cancers, ovarian cancer represents the leading cause of death in
women. Current treatment for ovarian cancer entails surgery followed by combined …

Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT)

N Maleki, N Yavari, M Ebrahimi, AF Faiz, RK Ravesh… - Gene, 2022 - Elsevier
Background Silibinin, the principal flavonoid derived from milk thistle seeds, has been
demonstrated to have strong inhibitory effects against human malignancies. The inhibitory …

The role of natural and semi-synthetic compounds in ovarian cancer: Updates on mechanisms of action, current trends and perspectives

MR Islam, MM Rahman, PS Dhar, FT Nowrin… - Molecules, 2023 - mdpi.com
Ovarian cancer represents a major health concern for the female population: there is no
obvious cause, it is frequently misdiagnosed, and it is characterized by a poor prognosis …

Pharmacophore-driven identification of human glutaminyl cyclase inhibitors from foods, plants and herbs unveils the bioactive property and potential of Azaleatin in …

KC Tsai, YX Zhang, HY Kao, KM Fung, TS Tseng - Food & Function, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is the leading cause of disabilities in old age and a rapidly
growing condition in the elderly population. AD brings significant burden and has a …