Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni

J Wang, R Chen, JJ Collins III - PLoS biology, 2019 - journals.plos.org
Schistosomes infect over 200 million people. The prodigious egg output of these parasites is
the sole driver of pathology due to infection, yet our understanding of sexual reproduction by …

Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum

J Wang, Y Yu, H Shen, T Qing, Y Zheng, Q Li… - Nature …, 2017 - nature.com
Eggs produced by the mature female parasite are responsible for the pathogenesis and
transmission of schistosomiasis. Female schistosomes rely on a unique male-induced …

Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum

S Cheng, Y You, X Wang, C Yi, W Zhang, Y Xie… - Plos …, 2024 - journals.plos.org
Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts.
The regulation of the parasite's developmental processes relies on both coding RNAs and …

Modulation of mitochondrial metabolism as a biochemical trait in blood feeding organisms: The redox vampire hypothesis redux

CM Ferreira, MP Oliveira, MC Paes… - Cell Biology …, 2018 - Wiley Online Library
Hematophagous organisms undergo remarkable metabolic changes during the blood
digestion process, increasing fermentative glucose metabolism, and reducing respiratory …

Failure of in vitro-cultured schistosomes to produce eggs: how does the parasite meet its needs for host-derived cytokines such as TGF-β?

MJ Doenhoff, J Modha, AJ Walker - International journal for parasitology, 2019 - Elsevier
When adult schistosome worm pairs are transferred from experimental hosts to in vitro
culture they cease producing viable eggs within a few days. Female worms in unisexual …

Comparative analysis of iTRAQ-based proteome profiles of Schistosoma japonicum female worms coming from single-sex infections and bisexual infections

X Li, H Qiao, F Qin, G Cheng, J Liu, H Li, S Gu… - Journal of proteomics, 2020 - Elsevier
In schistosomiasis, eggs produced by bisexual infected mature female schistosome worms
(FMS) are the main cause of pathological damage to the host and the dissemination of the …

Calpain inhibitor suppresses both extracellular vesicle-mediated secretion of miRNAs and egg production from paired adults of Schistosoma japonicum

T Kumagai, R Shimogawara, K Ichimura… - Parasitology …, 2022 - Elsevier
Extracellular vesicles (EVs) have been reported to be secreted from Schistosoma japonicum
at all developmental stages. However, the reproduction and communication mechanisms …

An improved medium for in vitro studies of female reproduction and oviposition in Schistosoma japonicum

Y You, X Chen, L Huo, L Chen, G Chen, M Gu, C Yi… - Parasites & …, 2024 - Springer
Background Schistosomiasis is a disease primarily caused by eggs laid by pathogens called
schistosomes. Among the schistosome species infecting humans, Schistosoma japonicum …

Identification and characterisation of the haemozoin of Haemonchus contortus

L Liu, Z Zhang, H Liu, S Zhu, T Zhou, C Wang, M Hu - Parasites & Vectors, 2023 - Springer
Background Most haematophagous organisms constantly suck the host's haemoglobin,
which produces toxic free haem. This toxic haem aggregation into the nontoxic …

A self-purifying microfluidic system for identifying drugs acting against adult schistosomes

V Girod, R Houssier, K Sahmer… - Royal Society …, 2022 - royalsocietypublishing.org
The discovery of novel antihelmintic molecules to combat the development and spread of
schistosomiasis, a disease caused by several Schistosoma flatworm species, mobilizes …