Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni
Schistosomes infect over 200 million people. The prodigious egg output of these parasites is
the sole driver of pathology due to infection, yet our understanding of sexual reproduction by …
the sole driver of pathology due to infection, yet our understanding of sexual reproduction by …
Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum
Eggs produced by the mature female parasite are responsible for the pathogenesis and
transmission of schistosomiasis. Female schistosomes rely on a unique male-induced …
transmission of schistosomiasis. Female schistosomes rely on a unique male-induced …
Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum
S Cheng, Y You, X Wang, C Yi, W Zhang, Y Xie… - Plos …, 2024 - journals.plos.org
Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts.
The regulation of the parasite's developmental processes relies on both coding RNAs and …
The regulation of the parasite's developmental processes relies on both coding RNAs and …
Modulation of mitochondrial metabolism as a biochemical trait in blood feeding organisms: The redox vampire hypothesis redux
Hematophagous organisms undergo remarkable metabolic changes during the blood
digestion process, increasing fermentative glucose metabolism, and reducing respiratory …
digestion process, increasing fermentative glucose metabolism, and reducing respiratory …
Failure of in vitro-cultured schistosomes to produce eggs: how does the parasite meet its needs for host-derived cytokines such as TGF-β?
MJ Doenhoff, J Modha, AJ Walker - International journal for parasitology, 2019 - Elsevier
When adult schistosome worm pairs are transferred from experimental hosts to in vitro
culture they cease producing viable eggs within a few days. Female worms in unisexual …
culture they cease producing viable eggs within a few days. Female worms in unisexual …
Comparative analysis of iTRAQ-based proteome profiles of Schistosoma japonicum female worms coming from single-sex infections and bisexual infections
X Li, H Qiao, F Qin, G Cheng, J Liu, H Li, S Gu… - Journal of proteomics, 2020 - Elsevier
In schistosomiasis, eggs produced by bisexual infected mature female schistosome worms
(FMS) are the main cause of pathological damage to the host and the dissemination of the …
(FMS) are the main cause of pathological damage to the host and the dissemination of the …
Calpain inhibitor suppresses both extracellular vesicle-mediated secretion of miRNAs and egg production from paired adults of Schistosoma japonicum
T Kumagai, R Shimogawara, K Ichimura… - Parasitology …, 2022 - Elsevier
Extracellular vesicles (EVs) have been reported to be secreted from Schistosoma japonicum
at all developmental stages. However, the reproduction and communication mechanisms …
at all developmental stages. However, the reproduction and communication mechanisms …
An improved medium for in vitro studies of female reproduction and oviposition in Schistosoma japonicum
Y You, X Chen, L Huo, L Chen, G Chen, M Gu, C Yi… - Parasites & …, 2024 - Springer
Background Schistosomiasis is a disease primarily caused by eggs laid by pathogens called
schistosomes. Among the schistosome species infecting humans, Schistosoma japonicum …
schistosomes. Among the schistosome species infecting humans, Schistosoma japonicum …
Identification and characterisation of the haemozoin of Haemonchus contortus
L Liu, Z Zhang, H Liu, S Zhu, T Zhou, C Wang, M Hu - Parasites & Vectors, 2023 - Springer
Background Most haematophagous organisms constantly suck the host's haemoglobin,
which produces toxic free haem. This toxic haem aggregation into the nontoxic …
which produces toxic free haem. This toxic haem aggregation into the nontoxic …
A self-purifying microfluidic system for identifying drugs acting against adult schistosomes
V Girod, R Houssier, K Sahmer… - Royal Society …, 2022 - royalsocietypublishing.org
The discovery of novel antihelmintic molecules to combat the development and spread of
schistosomiasis, a disease caused by several Schistosoma flatworm species, mobilizes …
schistosomiasis, a disease caused by several Schistosoma flatworm species, mobilizes …