Oxidative stress in traumatic brain injury

A Fesharaki-Zadeh - International journal of molecular sciences, 2022 - mdpi.com
Traumatic Brain Injury (TBI) remains a major cause of disability worldwide. It involves a
complex neurometabolic cascade, including oxidative stress. The products of this …

Antioxidant therapies in traumatic brain injury

V Di Pietro, KM Yakoub, G Caruso, G Lazzarino… - Antioxidants, 2020 - mdpi.com
Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly
heterogeneous pathology, characterized by high mortality and disability rates. TBI is an …

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

B Hakiminia, B Alikiaii, F Khorvash… - Fundamental & …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …

Therapeutic targeting of microglia mediated oxidative stress after neurotrauma

AN Smith, M Shaughness, S Collier, D Hopkins… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a primary component of the central nervous system injury response.
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …

Ferroptosis and traumatic brain injury

Z Geng, Z Guo, R Guo, R Ye, W Zhu, B Yan - Brain Research Bulletin, 2021 - Elsevier
Traumatic brain injury (TBI) is a worldwide health problem contributing to significant
economic burden. TBI is difficult to treat partly due to incomplete understanding of …

Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury

I Lisi, F Moro, E Mazzone, N Marklund, F Pischiutta… - Brain, 2024 - academic.oup.com
Rodent models are important research tools for studying the pathophysiology of traumatic
brain injury (TBI) and developing new therapeutic interventions for this devastating …

Ubiquinol preserves immune cells in gamma-irradiated rats: Role of autophagy and apoptosis in splenic tissue

NM Elkenawy, HR Ghaiad, SM Ibrahim, RK Aziz… - International …, 2023 - Elsevier
Radiation has been applied in cancer treatment to eradicate tumors and displayed great
therapeutic benefits for humans. However, it is associated with negative impacts on normal …

TMT-based proteomics analysis to screen potential biomarkers of acute-phase TBI in rats

H Wang, J Chen, C Gao, W Chen, G Chen, M Zhang… - Life Sciences, 2021 - Elsevier
Aims Traumatic brain injury (TBI) is a common nervous system injury. However, the detailed
mechanisms about functional dysregulation and dignostic biomarkers post-TBI are still …

The neuroprotective effect and possible therapeutic application of xenon in neurological diseases

M Zhang, Y Cui, Y Cheng, Q Wang… - Journal of Neuroscience …, 2021 - Wiley Online Library
Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent
in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect …

Effect of Bevacizumab on traumatic penumbra brain edema in rats at different time points

L Ai, C Xin, M Usman, Y Zhu, H Lu - Tissue Barriers, 2024 - Taylor & Francis
Traumatic penumbra (TP) is a secondary injury area located around the core area of
traumatic brain injury after brain trauma, and is an important factor affecting the outcome of …