Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Connections among brain regions allow pathological perturbations to spread from a single
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …

Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Objective Clinical trials in amyotrophic lateral sclerosis (ALS) continue to rely on survival or
functional scales as endpoints, despite the emergence of quantitative biomarkers …

Background A mutation in C9orf72 constitute a cross-link between amyotrophic lateral
sclerosis (ALS) and fronto-temporal dementia (FTD). At clinical manifestation, both patient …

Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …