Cellular signaling operates in a noisy environment shaped by low molecular concentrations
and cellular heterogeneity. For calcium release through intracellular channels–one of the …

Calcium is an abundant element with a wide variety of important roles within cells. Calcium
ions are inter-and intra-cellular messengers that are involved in numerous signalling …

The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching
throughout the cell. Understanding how ER functionality relies on its structural organization …

Calcium puffs are local transient Ca 2+ releases from internal Ca 2+ stores such as the
endoplasmic reticulum or the sarcoplasmic reticulum. Such release occurs through a cluster …

Familial Alzheimer's disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,
4, 5-trisphosphate (IP3) receptor (IP3R) Ca2+ release channels resulting in enhanced IP3R …

Key points Calcium (Ca2+) entry mediated by NMDA receptors is considered central to the
induction of activity‐dependent synaptic plasticity in hippocampal area CA1; this description …

Intracellular calcium is regulated in part by the release of Ca ^2+ ions from the endoplasmic
reticulum via inositol-4, 5-triphosphate receptor (IP _3 R) channels (among other …

Calcium puffs are localized Ca 2+ signals mediated by Ca 2+ release from the endoplasmic
reticulum (ER) through clusters of inositol trisphosphate receptor (IP 3 R) channels. The …

Amyloid beta (Aβ) oligomers associated with Alzheimer's disease (AD) form Ca2+-
permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled …

Cardiac muscle contraction is initiated by an elementary Ca signal (called Ca spark) which
is achieved by collective action of Ca release channels in a cluster. The mechanism of this …