Informed consent procedures for emergency interventional research in patients with traumatic brain injury and ischaemic stroke
EJO Kompanje, JTJM van Dijck, V Chalos… - The Lancet …, 2020 - thelancet.com
Health-care professionals and researchers have a legal and ethical responsibility to inform
patients before carrying out diagnostic tests or treatment interventions as part of a clinical …
patients before carrying out diagnostic tests or treatment interventions as part of a clinical …
Trials using deferred consent in the emergency setting: a systematic review and narrative synthesis of stakeholders' attitudes
A Fitzpatrick, F Wood, V Shepherd - Trials, 2022 - Springer
Background Patients with acute conditions often lack the capacity to provide informed
consent, and narrow therapeutic windows mean there is no time to seek consent from …
consent, and narrow therapeutic windows mean there is no time to seek consent from …
MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a …
FAVA Pirson, WH Hinsenveld, RJB Goldhoorn, J Staals… - Trials, 2021 - Springer
Background Endovascular therapy (EVT) for acute ischemic stroke due to proximal
occlusion of the anterior intracranial circulation, started within 6 h from symptom onset, has …
occlusion of the anterior intracranial circulation, started within 6 h from symptom onset, has …
Effect of high-flow nasal cannula therapy vs continuous positive airway pressure therapy on liberation from respiratory support in acutely ill children admitted to …
P Ramnarayan, A Richards-Belle, L Drikite, M Saull… - JAMA, 2022 - jamanetwork.com
Importance The optimal first-line mode of noninvasive respiratory support for acutely ill
children is not known. Objective To evaluate the noninferiority of high-flow nasal cannula …
children is not known. Objective To evaluate the noninferiority of high-flow nasal cannula …
Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial
RE Gilbert, Q Mok, K Dwan, K Harron, T Moitt, M Millar… - The Lancet, 2016 - thelancet.com
Background Impregnated central venous catheters are recommended for adults to reduce
bloodstream infections but not for children because there is not enough evidence to prove …
bloodstream infections but not for children because there is not enough evidence to prove …
How parents and practitioners experience research without prior consent (deferred consent) for emergency research involving children with life threatening conditions …
Objective Alternatives to prospective informed consent to enable children with life-
threatening conditions to be entered into trials of emergency treatments are needed. Across …
threatening conditions to be entered into trials of emergency treatments are needed. Across …
MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal …
KM Treurniet, NE LeCouffe, M Kappelhof, BJ Emmer… - Trials, 2021 - Springer
Background Endovascular treatment (EVT) has greatly improved the prognosis of acute
ischemic stroke (AIS) patients with a proximal intracranial large vessel occlusion (LVO) of …
ischemic stroke (AIS) patients with a proximal intracranial large vessel occlusion (LVO) of …
Effect of high-flow nasal cannula therapy vs continuous positive airway pressure following extubation on liberation from respiratory support in critically ill children: a …
P Ramnarayan, A Richards-Belle, L Drikite, M Saull… - Jama, 2022 - jamanetwork.com
Importance The optimal first-line mode of noninvasive respiratory support following
extubation of critically ill children is not known. Objective To evaluate the noninferiority of …
extubation of critically ill children is not known. Objective To evaluate the noninferiority of …
FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus …
P Ramnarayan, P Lister, T Dominguez, P Habibi… - Critical Care, 2018 - Springer
Background Although high-flow nasal cannula therapy (HFNC) has become a popular mode
of non-invasive respiratory support (NRS) in critically ill children, there are no randomised …
of non-invasive respiratory support (NRS) in critically ill children, there are no randomised …
Protocol for a randomized multiple center trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): Oxygen in pediatric intensive care
I Chang, K Thomas, LON Gutierrez… - Pediatric Critical Care …, 2022 - journals.lww.com
OBJECTIVES: Oxygen administration is a fundamental part of pediatric critical care, with
supplemental oxygen offered to nearly every acutely unwell child. However, optimal targets …
supplemental oxygen offered to nearly every acutely unwell child. However, optimal targets …