Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …

Tissue repair models are essential to explore the pathogenesis of wound healing and scar
formation, identify new drug targets/biomarkers and to test new therapeutics. However, no …

The keratinocyte growth and differentiation switch, tightly regulated by several mechanisms,
is generally associated with decreased proliferation, cell cycle arrest in G0/G1 phase and …

Abstract Agent-based modeling (ABM), also termed 'Individual-based modeling (IBM)', is a
computational approach that simulates the interactions of autonomous entities (agents, or …

This article is a critical review of computational techniques used to model, analyse and
simulate signalling networks. We propose a conceptual framework, and discuss the role of …

A comprehensive in vitro approach was used to assess the effects of superabsorbent
polymer (SAP) containing wound dressings in treatment of non-healing wounds. A slight …

Capturing the dynamism that pervades biological systems requires a computational
approach that can accommodate both the continuous features of the system environment as …

The strikingly even color of human skin is maintained by the uniform distribution of
melanocytes among keratinocytes in the basal layer of the human epidermis. In this work …

Closely coupled in vitro and in virtuo models have been used to explore the self-
organization of normal human keratinocytes (NHK). Although it can be observed …

Background Burn injuries are devastating traumas that functionally affect a variety of organ
systems. As intensive inflammatory responses induced by burns can lead to multiple organ …