Enteric infections, with or without overt diarrhea, have profound effects on intestinal
absorption, nutrition, and childhood development as well as on global mortality. Oral …

Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet
under-appreciated global burden of invasive disease. In South and South-East Asia, this …

Understanding the mechanisms underlying the induction of immunity in the gastrointestinal
mucosa following oral immunization and the cross‐talk between mucosal and systemic …

Oral vaccines, whether living or non-living, viral or bacterial, elicit diminished immune
responses or have lower efficacy in developing countries than in developed countries. Here …

Although Salmonella enterica serovars are some of the beststudied bacterial pathogens, the
field still has a long way to go, especially when one considers that (i) they cause significant …

The development of improved typhoid vaccines is a high global public health priority.
However, their development has been hampered by a lack of information regarding the …

B and T cells are key components of the adaptive immune system and coordinate multiple
facets of immunity including responses to infection, vaccines, allergens, and the …

A common finding when measuring T cell immunity to enteric bacterial vaccines in humans
is the presence of background responses among individuals before immunization. Yet the …

Attenuated Salmonella Typhi vaccine strains hold great promise as live vectors for
presentation of foreign antigens from unrelated bacterial, viral and parasitic pathogens to the …

Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, and S.
Paratyphi A and B, causative agents of paratyphoid fever, are major public health threats …