Linking prenatal environmental exposures to lifetime health with epigenome-wide association studies: state-of-the-science review and future recommendations
Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
Challenges and perspectives in computational deconvolution of genomics data
Deciphering cell-type heterogeneity is crucial for systematically understanding tissue
homeostasis and its dysregulation in diseases. Computational deconvolution is an efficient …
homeostasis and its dysregulation in diseases. Computational deconvolution is an efficient …
A DNA methylation atlas of normal human cell types
DNA methylation is a fundamental epigenetic mark that governs gene expression and
chromatin organization, thus providing a window into cellular identity and developmental …
chromatin organization, thus providing a window into cellular identity and developmental …
Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle
Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …
diseases and environmental risk factors and may be causally implicated in disease …
Methylation differences in Alzheimer's disease neuropathologic change in the aged human brain
Alzheimer's disease (AD) is the most common cause of dementia with advancing age as its
strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with …
strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with …
[PDF][PDF] A phase II trial of guadecitabine plus atezolizumab in metastatic urothelial carcinoma progressing after initial immune checkpoint inhibitor therapy
HJ Jang, G Hostetter, AW Macfarlane, Z Madaj… - Clinical Cancer …, 2023 - AACR
Purpose: On the basis of preclinical evidence of epigenetic contribution to sensitivity and
resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine …
resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine …
NTRK‐rearranged spindle cell neoplasms are ubiquitous tumours of myofibroblastic lineage with a distinct methylation class
A Tauziède‐Espariat, M Duchesne, J Baud… - …, 2023 - Wiley Online Library
Aims NTRK gene fusions have been described in a wide variety of central nervous system
(CNS) and soft tissue tumours, including the provisional tumour type 'spindle cell neoplasm …
(CNS) and soft tissue tumours, including the provisional tumour type 'spindle cell neoplasm …
Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation
Introduction The human brain comprises heterogeneous cell types whose composition can
be altered with physiological and pathological conditions. New approaches to discern the …
be altered with physiological and pathological conditions. New approaches to discern the …
Genetic effects on the skin methylome in healthy older twins
CJ Shore, S Villicaña, JSES Moustafa… - The American Journal of …, 2024 - cell.com
Whole-skin DNA methylation variation has been implicated in several diseases, including
melanoma, but its genetic basis has not yet been fully characterized. Using bulk skin tissue …
melanoma, but its genetic basis has not yet been fully characterized. Using bulk skin tissue …