[HTML][HTML] Hippo pathway in organ size control, tissue homeostasis, and cancer
Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …
The Hippo pathway and human cancer
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …
can induce tumours in model organisms and occurs in a broad range of human carcinomas …
[HTML][HTML] Loss of the FAT1 tumor suppressor promotes resistance to CDK4/6 inhibitors via the hippo pathway
Summary Cyclin dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) are effective in breast
cancer; however, drug resistance is frequently encountered and poorly understood. We …
cancer; however, drug resistance is frequently encountered and poorly understood. We …
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …
The Hippo pathway: regulators and regulations
Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …
[HTML][HTML] The hippo signaling pathway in development and cancer
D Pan - Developmental cell, 2010 - cell.com
First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
B Zhao, K Tumaneng, KL Guan - Nature cell biology, 2011 - nature.com
Precise control of organ size is crucial during animal development and regeneration. In
Drosophila and mammals, studies over the past decade have uncovered a critical role for …
Drosophila and mammals, studies over the past decade have uncovered a critical role for …
Hippo pathway regulation by cell morphology and stress fibers
The Hippo signaling pathway plays an important role in regulation of cell proliferation. Cell
density regulates the Hippo pathway in cultured cells; however, the mechanism by which …
density regulates the Hippo pathway in cultured cells; however, the mechanism by which …
Hippo signaling: growth control and beyond
G Halder, RL Johnson - Development, 2011 - journals.biologists.com
The Hippo pathway has emerged as a conserved signaling pathway that is essential for the
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …
The Hippo–YAP pathway in organ size control and tumorigenesis: an updated version
The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …
size control and tumorigenesis, which are physiological and pathological processes that …