Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

Summary Cyclin dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) are effective in breast
cancer; however, drug resistance is frequently encountered and poorly understood. We …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

Precise control of organ size is crucial during animal development and regeneration. In
Drosophila and mammals, studies over the past decade have uncovered a critical role for …

The Hippo signaling pathway plays an important role in regulation of cell proliferation. Cell
density regulates the Hippo pathway in cultured cells; however, the mechanism by which …

The Hippo pathway has emerged as a conserved signaling pathway that is essential for the
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …

The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …