Advances in antibody design
KE Tiller, PM Tessier - Annual review of biomedical engineering, 2015 - annualreviews.org
The use of monoclonal antibodies as therapeutics requires optimizing several of their key
attributes. These include binding affinity and specificity, folding stability, solubility …
attributes. These include binding affinity and specificity, folding stability, solubility …
[HTML][HTML] Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement
Dengue is the most common viral infection spread by mosquitoes, prevalent in tropical
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …
[HTML][HTML] Structure-guided design of an anti-dengue antibody directed to a non-immunodominant epitope
LN Robinson, K Tharakaraman, KJ Rowley, VV Costa… - Cell, 2015 - cell.com
Dengue is the most common vector-borne viral disease, causing nearly 400 million
infections yearly. Currently there are no approved therapies. Antibody epitopes that elicit …
infections yearly. Currently there are no approved therapies. Antibody epitopes that elicit …
[HTML][HTML] Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics
Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes
(DENV1-4) that are spreading into new territories is an important goal of vaccine design. To …
(DENV1-4) that are spreading into new territories is an important goal of vaccine design. To …
Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist
C Zuo, WW Shi, XX Chen, M Glatz, B Riedl… - Science China …, 2019 - Springer
Blockade of the interaction of anaphylatoxin C5a with its receptor C5aR1 has been actively
studied as a potential treatment for many inflammatory diseases; but current C5a …
studied as a potential treatment for many inflammatory diseases; but current C5a …
[HTML][HTML] Structural vaccinology for viral vaccine design
Although vaccines have proven pivotal against arrays of infectious viral diseases, there are
still no effective vaccines against many viruses. New structural insights into the viral …
still no effective vaccines against many viruses. New structural insights into the viral …
[HTML][HTML] Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs
Antibodies commonly accumulate charged mutations in their complementarity-determining
regions (CDRs) during affinity maturation to enhance electrostatic interactions. However …
regions (CDRs) during affinity maturation to enhance electrostatic interactions. However …
A broadly neutralizing human monoclonal antibody is effective against H7N9
K Tharakaraman, V Subramanian… - Proceedings of the …, 2015 - National Acad Sciences
Emerging strains of influenza represent a significant public health threat with potential
pandemic consequences. Of particular concern are the recently emerged H7N9 strains …
pandemic consequences. Of particular concern are the recently emerged H7N9 strains …
[HTML][HTML] Development of antibody therapeutics against flaviviruses
Recent outbreaks of Zika virus (ZIKV) highlight the urgent need to develop efficacious
interventions against flaviviruses, many of which cause devastating epidemics around the …
interventions against flaviviruses, many of which cause devastating epidemics around the …
Scoring functions for protein–protein interactions
Highlights•Scoring can have implications for medicine, evolution and systems
biology.•Mutual information in functions designed for different task is yet to be …
biology.•Mutual information in functions designed for different task is yet to be …