Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
Physiological functions of bacterial “multidrug” efflux pumps
PJF Henderson, C Maher, LDH Elbourne… - Chemical …, 2021 - ACS Publications
Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …
pathogenesis because they help bacteria protect themselves against the antimicrobials …
Structural and functional diversity of resistance–nodulation–cell division transporters
Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …
becoming increasingly difficult to eliminate. While significant effort has gone into the …
Biocidal resistance in clinically relevant microbial species: a major public health risk
Antimicrobial resistance is one of the greatest dangers to public health of the 21st century,
threatening the treatment and prevention of infectious diseases globally. Disinfection, the …
threatening the treatment and prevention of infectious diseases globally. Disinfection, the …
Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR
GM Hooks, JC Ayala, CL Holley, V Dhulipala… - Nature …, 2024 - nature.com
Transcriptional regulator MtrR inhibits the expression of the multidrug efflux pump operon
mtrCDE in the pathogenic bacterium Neisseria gonorrhoeae. Here, we show that MtrR binds …
mtrCDE in the pathogenic bacterium Neisseria gonorrhoeae. Here, we show that MtrR binds …
The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila
T Hagi, SY Geerlings, B Nijsse, C Belzer - Applied Microbiology and …, 2020 - Springer
Akkermansia muciniphila is a prominent member of the gut microbiota and the organism
gets exposed to bile acids within this niche. Several gut bacteria have bile response genes …
gets exposed to bile acids within this niche. Several gut bacteria have bile response genes …
Cryo-EM structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition and resistance
M Lyu, MA Moseng, JL Reimche, CL Holley… - Mbio, 2020 - Am Soc Microbiol
Neisseria gonorrhoeae is an obligate human pathogen and causative agent of the sexually
transmitted infection (STI) gonorrhea. The most predominant and clinically important …
transmitted infection (STI) gonorrhea. The most predominant and clinically important …
The oral microbiota of wild bears in Sweden reflects the history of antibiotic use by humans
Following the advent of industrial-scale antibiotic production in the 1940s, 1 antimicrobial
resistance (AMR) has been on the rise and now poses a major global health threat in terms …
resistance (AMR) has been on the rise and now poses a major global health threat in terms …
RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pump
Acinetobacter are generally soil-dwelling organisms that can also cause serious human
infections. A. baumannii is one of the most common causative agents of Acinetobacter …
infections. A. baumannii is one of the most common causative agents of Acinetobacter …
Cryo-EM structures of the Klebsiella pneumoniae AcrB multidrug efflux pump
The continued challenges of the COVID-19 pandemic combined with the growing problem of
antimicrobial-resistant bacterial infections has severely impacted global health. Specifically …
antimicrobial-resistant bacterial infections has severely impacted global health. Specifically …