Specialized subpopulations of deep-layer pyramidal neurons in the neocortex: bridging cellular properties to functional consequences
Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …
Cardiac and neuronal HCN channelopathies
I Rivolta, A Binda, A Masi, JC DiFrancesco - Pflügers Archiv-European …, 2020 - Springer
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders
B Santoro, MM Shah - Annual review of pharmacology and …, 2020 - annualreviews.org
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
L Sartiani, G Mannaioni, A Masi, MN Romanelli… - Pharmacological …, 2017 - ASPET
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
The hyperpolarization-activated HCN4 channel is important for proper maintenance of oscillatory activity in the thalamocortical system
M Zobeiri, R Chaudhary, A Blaich, M Rottmann… - Cerebral …, 2019 - academic.oup.com
Hyperpolarization-activated cation channels are involved, among other functions, in learning
and memory, control of synaptic transmission and epileptogenesis. The importance of the …
and memory, control of synaptic transmission and epileptogenesis. The importance of the …
[HTML][HTML] HCN channels and absence seizures
Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …
[HTML][HTML] Regulation of HCN channels by protein interactions
Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …
[HTML][HTML] The contribution of HCN channelopathies in different epileptic syndromes, mechanisms, modulators, and potential treatment targets: a systematic review
M Kessi, J Peng, H Duan, H He, B Chen… - Frontiers in Molecular …, 2022 - frontiersin.org
Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …
Neuroinflammation alters integrative properties of rat hippocampal pyramidal cells
Neuroinflammation is consistently found in many neurological disorders, but whether or not
the inflammatory response independently affects neuronal network properties is poorly …
the inflammatory response independently affects neuronal network properties is poorly …
HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects
Major depressive disorder (MDD) is a prevalent psychiatric condition with limited therapeutic
options beyond monoaminergic therapies. Although effective in some individuals, many …
options beyond monoaminergic therapies. Although effective in some individuals, many …