In the DSM5, negative symptoms are 1 of the 5 core dimensions of psychopathology
evaluated for schizophrenia. However, negative symptoms are not pathognomonic—they …

Negative symptoms in schizophrenia may be classified as primary or secondary. Primary
negative symptoms are thought to be intrinsic to schizophrenia, while secondary negative …

Importance Abnormal reward processing is suggested to underlie the formation of psychotic
symptoms, likely driven by elevated ventral striatal (VS) dopamine levels. Functional …

The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes
misattribution of salience to irrelevant stimuli leading to psychosis. Recently, new lines of …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

The associations among normal personality and many mental disorders are well
established, but it remains unclear whether and how symptoms of schizophrenia and …

Emerging evidence has attributed altered network coordination between the default mode,
central executive, and salience networks (DMN/CEN/SAL) to disturbances seen in …

In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early
symptomatic course of schizophrenia and first in vivo evidence of accompanying brain …

A priority for improving outcome in individuals at clinical high risk (CHR) is enhancing our
understanding of predictors of psychosis as well as psychosocial functioning. Social …

Accumulating evidence points towards the antipsychotic potential of cannabidiol. However,
the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain …