Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …

Targeted protein degradation using the PROTAC technology is emerging as a novel
therapeutic method to address diseases driven by the aberrant expression of a disease …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …

Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …

Many diseases appear to be caused by the misregulation of protein maintenance. Such
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …

Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD),
and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …