Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
Strategies for developing sensitive and specific nanoparticle-based lateral flow assays as point-of-care diagnostic device
From a home-based pregnancy self-testing kit, lateral flow assays (LFAs) have proliferated
and gained widespread utilization as point-of-care (POC) test kits. Their prevalence is due to …
and gained widespread utilization as point-of-care (POC) test kits. Their prevalence is due to …
SARS-CoV-2 viral load is associated with increased disease severity and mortality
J Fajnzylber, J Regan, K Coxen, H Corry… - Nature …, 2020 - nature.com
The relationship between SARS-CoV-2 viral load and risk of disease progression remains
largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 …
largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 …
Pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): clinical presentation, infectivity, and immune responses
Objectives As schools plan for re-opening, understanding the potential role children play in
the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive …
the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive …
Cone-shaped HIV-1 capsids are transported through intact nuclear pores
Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …
uncoating and nuclear import of the viral genome are critical for productive infection. The …
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after …
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after …
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo
OS Søgaard, ME Graversen, S Leth, R Olesen… - PLoS …, 2015 - journals.plos.org
Pharmacologically-induced activation of replication competent proviruses from latency in the
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
The viral reservoir represents a critical challenge for human immunodeficiency virus type 1
(HIV-1) eradication strategies,,,,. However, it remains unclear when and where the viral …
(HIV-1) eradication strategies,,,,. However, it remains unclear when and where the viral …
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
N Pardi, AJ Secreto, X Shan, F Debonera… - Nature …, 2017 - nature.com
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products,
however, their potential is limited by the high cost of development and manufacturing. Here …
however, their potential is limited by the high cost of development and manufacturing. Here …