Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Recent trends in protein and peptide-based biomaterials for advanced drug delivery
Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …
momentum due to their biochemical and biophysical properties over synthetic materials …
Genomic RNA elements drive phase separation of the SARS-CoV-2 nucleocapsid
C Iserman, CA Roden, MA Boerneke, RSG Sealfon… - Molecular cell, 2020 - cell.com
We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …
Elastin-like polypeptides for biomedical applications
AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …
elastin. Their unique properties—including lower critical solution temperature phase …
Stimuli-responsive, pentapeptide, nanofiber hydrogel for tissue engineering
Short peptides are uniquely versatile building blocks for self-assembly. Supramolecular
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …
Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers
FG Quiroz, A Chilkoti - Nature materials, 2015 - nature.com
Proteins and synthetic polymers that undergo aqueous phase transitions mediate self-
assembly in nature and in man-made material systems. Yet little is known about how the …
assembly in nature and in man-made material systems. Yet little is known about how the …
Coacervate droplets for synthetic cells
The design and construction of synthetic cells–human‐made microcompartments that mimic
features of living cells–have experienced a real boom in the past decade. While many efforts …
features of living cells–have experienced a real boom in the past decade. While many efforts …
[HTML][HTML] Elastin-like polypeptides as models of intrinsically disordered proteins
S Roberts, M Dzuricky, A Chilkoti - FEBS letters, 2015 - Elsevier
Elastin-like polypeptides (ELPs) are a class of stimuli-responsive biopolymers inspired by
the intrinsically disordered domains of tropoelastin that are composed of repeats of the …
the intrinsically disordered domains of tropoelastin that are composed of repeats of the …
Advances in understanding stimulus-responsive phase behavior of intrinsically disordered protein polymers
Proteins and synthetic polymers can undergo phase transitions in response to changes to
intensive solution parameters such as temperature, proton chemical potentials (pH), and …
intensive solution parameters such as temperature, proton chemical potentials (pH), and …
Cononsolvency of thermoresponsive polymers: where we are now and where we are going
Cononsolvency is an intriguing phenomenon where a polymer collapses in a mixture of
good solvents. This cosolvent-induced modulation of the polymer solubility has been …
good solvents. This cosolvent-induced modulation of the polymer solubility has been …