Extracellular vesicles: A bright star of nanomedicine

P Wu, B Zhang, DKW Ocansey, W Xu, H Qian - Biomaterials, 2021 - Elsevier
Extracellular vesicles (EVs) have unique structural, compositional, and morphological
characteristics as well as predominant physiochemical stability and biocompatibility …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

J Zhao, X Li, J Hu, F Chen, S Qiao, X Sun… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …

A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair

K Sun, Y Li, J Jin - Signal transduction and targeted therapy, 2021 - nature.com
The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

S Li, Z Lin, X Jiang, X Yu - Acta Pharmacologica Sinica, 2018 - nature.com
Exosomes are nano-sized vesicles that serve as mediators for intercellular communication
through the delivery of cargo, including protein, lipids, nucleic acids or other cellular …

Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration

ZW Luo, YW Liu, SS Rao, H Yin, J Huang, CY Chen… - Nanoscale, 2019 - pubs.rsc.org
In elderly people particularly in postmenopausal women, inadequate bone formation by
osteoblasts originating from bone marrow mesenchymal stem cells (BMSCs) for …

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

SW Ferguson, J Wang, CJ Lee, M Liu… - Scientific reports, 2018 - nature.com
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of
diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite …

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

B Liu, BW Lee, K Nakanishi, A Villasante… - Nature biomedical …, 2018 - nature.com
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has
recently been exploited for the treatment of diseases. For example, EVs secreted by …

[HTML][HTML] Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction

K Lv, Q Li, L Zhang, Y Wang, Z Zhong, J Zhao, X Lin… - Theranostics, 2019 - ncbi.nlm.nih.gov
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs)
have been widely used for treating myocardial infarction (MI). However, low retention and …

[HTML][HTML] miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

Z Wei, S Qiao, J Zhao, Y Liu, Q Li, Z Wei, Q Dai, L Kang… - Life sciences, 2019 - Elsevier
Aims The inflammation modulation effects of mesenchymal stromal cell-derived exosomes
(MSC-EXO) are well established. We aimed to explore the mechanism behind the …