The performance of the human brain is based on an interplay between the inherited
genotype and external environmental factors, including diet. Food and nutrition, essential in …

It was recently shown (Sampson et al., Elife 9, 2020) that an amyloidogenic protein, CsgA,
present in E. coli biofilms in the gut can trigger Parkinson's disease in mice. This study …

The deposition of proteins in the form of amyloid fibrils is closely associated with several
serious diseases. The events that trigger the conversion from soluble functional proteins into …

Amyloid fibers of the protein α-synuclein, found in Lewy body deposits, are hallmarks of
Parkinson's disease. We here show that α-synuclein amyloids catalyze biologically relevant …

The assembly of α-synuclein into cross-β structured amyloid fibers results in Lewy body
deposits and neuronal degeneration in Parkinson's disease patients. As the cell …

Aggregation and amyloid formation of the 140-residue presynaptic and intrinsically
disordered protein α-synuclein (α-syn) is a pathological hallmark of Parkinson's disease …

The crowdedness of living cells, hundreds of milligrams per milliliter of macromolecules,
may affect protein folding, function, and misfolding. Still, such processes are most often …

Optimal handling is the most important means to ensure adequate sample quality. We aimed
to investigate whether pre-centrifugation delay time and temperature could be accurately …

Alzheimer's disease (AD) is the most common type of dementia. Impact of air pollution (AP)
on the risk of AD is unclear. It is unknown which air pollutants are independently associated …

Intestinal dysbiosis seems to play a role in neurodegenerative pathologies. Parkinson's
disease (PD) patients have an altered gut microbiota. Moreover, mice treated orally with the …