BACKGROUND Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are
essential in human ovarian folliculogenesis. However, the interactions between these four …

The assembly of the primordial follicles early in ovarian development and the subsequent
development and transition of the primordial follicle to the primary follicle are critical …

In mammals, the final number of oocytes available for reproduction of the next generation is
defined at birth. Establishment of this oocyte pool is essential for fertility. Mammalian …

Aromatase is expressed in multiple tissues, indicating a crucial role for locally produced
oestrogens in the differentiation, regulation and normal function of several organs and …

The embryonic origins of ovarian granulosa cells have been a subject of debate for
decades. By tamoxifen-induced lineage tracing of Foxl2-expressing cells, we show that …

Estrogens are synthesized by the aromatase enzyme encoded by the Cyp19a1 gene, which
contains an unusually large regulatory region. In most mammals, aromatase expression is …

Individuals may regard reproduction as optional but sufficient number of them must be
productive to perpetuate the species. The reproductive system is surprisingly vulnerable and …

Female fertility in mammals is determined by the pool of primordial follicles and low doses of
radiation induce a major loss of primordial follicles in the ovary. We investigated the …

Mifepristone (MIF) administration to cycling rats at proestrus induces hypersecretion of
prolactin (PRL) at the following estrus. We aimed to assess whether this effect is due to the …

Reports indicate that germ-line stem cells present in adult mice can rapidly generate new
oocytes and contribute to the primordial follicle reserve following conditions of ovotoxic …