With recent outbreaks of COVID-19 and Ebola, health and healthcare have once more
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …

Sialic acids (Sias) are negatively charged functional monosaccharides present in a wide
variety of natural sources (plants, animals and microorganisms). Sias play an important role …

High performance is the core objective that biotechnologists pursue, of which low efficiency,
low titer, and side products are the chief obstacles. Here, a thermal strategy is proposed for …

Sialic acids (SAs) are important functional sugars, and monomers of sialylated human milk
oligosaccharides (sialylated HMOs or sialyllactoses), which are crucial for improving infant …

Biosynthetic cascades represent a transformative technology that is revolutionizing the way
chemists approach synthetic challenges and have set new standards for what constitutes …

N‐functionalized amines play important roles in nature and occur, for example, in the
antibiotic vancomycin, the immunosuppressant cyclosporine, the cytostatic actinomycin, the …

Microbial biorefineries to produce chemicals from renewable feedstock provides attractive
advantages, including mild reaction conditions and sustainable manufacturing. However …

Abstract N-Acetylneuraminic acid (Neu5Ac), the most common type of Sia, generally acts as
the terminal sugar in cell surface glycans, glycoconjugates, oligosaccharides, lipo …

Acetyl-CoA is an essential central metabolite in living organisms and a key precursor for
various value-added products as well. However, the intracellular availability of acetyl-CoA …

N-Acetyl-d-neuraminic acid (Neu5Ac) is a potential baby nutrient and the key precursor of
antiflu medicine Zanamivir. The Neu5Ac chemoenzymatic synthesis consists of N-acetyl-d …