Recent progress in quantitative phosphoproteomics

K Zittlau, P Nashier, C Cavarischia-Rega… - Expert Review of …, 2023 - Taylor & Francis
Introduction Protein phosphorylation is a critical post-translational modification involved in
the regulation of numerous cellular processes from signal transduction to modulation of …

Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages

A Gangwal, N Kumar, N Sangwan… - FEMS Microbiology …, 2023 - academic.oup.com
Protein phosphorylation is a universal mechanism regulating a wide range of cellular
responses across all domains of life. The antagonistic activities of kinases and …

Clostridioides difficile phosphoproteomics shows an expansion of phosphorylated proteins in stationary growth phase

WK Smits, Y Mohammed, AH de Ru, V Cordo'… - Msphere, 2022 - Am Soc Microbiol
Phosphorylation is a posttranslational modification that can affect both housekeeping
functions and virulence characteristics in bacterial pathogens. In the Gram-positive …

Automated phosphopeptide enrichment for gram-positive bacteria

MS Birk, E Charpentier, CK Frese - Journal of Proteome Research, 2021 - ACS Publications
Protein phosphorylation in prokaryotes has gained more attention in recent years as several
studies linked it to regulatory and signaling functions, indicating importance similar to protein …

Integrated mass spectrometry-based multi-omics for elucidating mechanisms of bacterial virulence

L Man, WP Klare, AL Dale, JA Cain… - Biochemical Society …, 2021 - portlandpress.com
Despite being considered the simplest form of life, bacteria remain enigmatic, particularly in
light of pathogenesis and evolving antimicrobial resistance. After three decades of …

Dynamic Protein Phosphorylation in Streptococcus pyogenes during Growth, Stationary Phase, and Starvation

S Mikkat, M Kreutzer, N Patenge - Microorganisms, 2024 - mdpi.com
Phosphorylation of proteins at serine, threonine, and tyrosine residues plays an important
role in physiological processes of bacteria, such as cell cycle, metabolism, virulence …

Protein Tyrosine and Serine/Threonine phosphorylation in oral bacterial dysbiosis and bacteria-host interaction

L Ren, D Shen, C Liu, Y Ding - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The human oral cavity harbors approximately 1,000 microbial species, and dysbiosis of the
microflora and imbalanced microbiota-host interactions drive many oral diseases, such as …

Tyrosine Kinases and Phosphatases: Enablers of the Porphyromonas gingivalis Lifestyle

RJ Lamont, DP Miller - Frontiers in Oral Health, 2022 - frontiersin.org
Tyrosine phosphorylation modifies the functionality of bacterial proteins and forms the basis
of a versatile and tunable signal transduction system. The integrated action of tyrosine …

Natural products from Brazilian biodiversity identified as potential inhibitors of PknA and PknB of M. tuberculosis using molecular modeling tools

SS Antunes, VWH Rabelo, NC Romeiro - Computers in Biology and …, 2021 - Elsevier
Mycobacterium tuberculosis was discovered in 1882 by Robert Koch but, since its discovery,
the tuberculosis (TB) epidemic has endured, being one of the top 10 causes of death …

The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria [S]

NH Le, M Locard-Paulet, A Stella, N Tomas… - Journal of Lipid …, 2020 - ASBMB
Mycobacterium tuberculosis is the causative agent of tuberculosis and remains one of the
most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of …