New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
MD Giraldez, D Carneros, C Garbers… - Nature reviews …, 2021 - nature.com
IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
M You, Z Xie, N Zhang, Y Zhang, D Xiao, S Liu… - … and Targeted Therapy, 2023 - nature.com
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …
be sensed by specific sensors, then trigger a series of signal transduction pathways and …
Genome-wide enhancer maps link risk variants to disease genes
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …
are associated with human diseases and complex traits, each of which could reveal insights …
Dynamics of prolyl hydroxylases levels during disease progression in experimental colitis
Hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitors are shown to be protective
in several models of inflammatory bowel disease (IBD). However, these non-selective …
in several models of inflammatory bowel disease (IBD). However, these non-selective …
[HTML][HTML] The diagnostic approach to monogenic very early onset inflammatory bowel disease
HH Uhlig, T Schwerd, S Koletzko, N Shah… - Gastroenterology, 2014 - Elsevier
Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …
The role of transcription factors in shaping regulatory T cell identity
Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
Intestinal barrier function in health and gastrointestinal disease
Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI)
tract. There is growing evidence that increases in intestinal permeability plays a pathogenic …
tract. There is growing evidence that increases in intestinal permeability plays a pathogenic …
Unravelling the effects of the environment and host genotype on the gut microbiome
To what extent do host genetics control the composition of the gut microbiome? Studies
comparing the gut microbiota in human twins and across inbred mouse lines have yielded …
comparing the gut microbiota in human twins and across inbred mouse lines have yielded …