Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized
by the formation of granulomatous lesions in the skin or other tissues, such as liver and …

Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …

Bacteria can use fatty acids (FAs) from their environment as carbon and energy source. This
catabolism is performed by the enzymes of the well-known β-oxidation machinery …

Highlights•Leishmania parasites possess a distinct lipidome from the mammalian
host.•Extracellular promastigotes use de novo synthesis to generate the majority of their …

Highlights•Intracellular amastigote stages of Leishmania activate a stringent metabolic
response.•The stringent response, triggered by H 2 O 2, involves extensive metabolic …

Leishmaniasis is one of the fast-growing parasitic diseases worldwide. The treatment of this
fatal disease presents a daunting challenge because of its adverse effects, necessity for …

Despite the development of a vaccine against cutaneous leishmaniasis in preclinical and
clinical studies, we still do not have a safe and effective vaccine for human use. Given this …

Docosahexaenoic acid (DHA) has attracted attention from researchers because of its
pharmacological and nutritional importance. Currently, DHA production costs are high due …

Obligate intracellular protozoan parasite, Leishmania donovani, causative agent of visceral
leishmaniasis, led to impaired macrophage functions. It is well documented that many of …