Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

This review traces the road leading to the demonstration of a variety of kojic acid chemical
and biological properties. It illustrates the biological effects of several synthetic kojic acid …

Herein we have reviewed our recent developments for the identification of new tacrine
analogues for Alzheimer's disease (AD) therapy. Tacrine, the first cholinesterase inhibitor …

A novel series of acridine derivatives containing substituted thiadiazol-2-amine moiety was
synthesized via multi-component condensation reaction of dimedone, aromatic aldehyde …

Multidrug resistance constitutes a serious obstacle of the treatment success of cancer by
chemotherapy. Mostly it is driven by expression of ABC transport proteins that actively efflux …

The aim of this work is to review tacrine analogues from the last three years, which were not
included in the latest review work, donepezil and galantamine hybrids from 2015 and …

Novel multitarget-directed ligands BIGI 4a-d and BIGI 5a-d were designed and synthesized
with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction …

Abstract Alzheimer′ s disease (AD), a neurodegenerative disease responsible for death of
millions of people worldwide is a progressive clinical disorder which causes neurons to …