[HTML][HTML] Neural control of breathing and CO2 homeostasis
PG Guyenet, DA Bayliss - Neuron, 2015 - cell.com
Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …
respiratory chemoreception). These mechanisms are reviewed and their significance is …
[HTML][HTML] Structural insights into the mechanisms and pharmacology of K2P potassium channels
AM Natale, PE Deal, DL Minor Jr - Journal of molecular biology, 2021 - Elsevier
Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
[HTML][HTML] Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis
JT Moore, J Chen, B Han, QC Meng, SC Veasey… - Current Biology, 2012 - cell.com
Background Despite seventeen decades of continuous clinical use, the neuronal
mechanisms through which volatile anesthetics act to produce unconsciousness remain …
mechanisms through which volatile anesthetics act to produce unconsciousness remain …
K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions
K2P potassium channels regulate cellular excitability using their selectivity filter (C-type)
gate. C-type gating mechanisms, best characterized in homotetrameric potassium channels …
gate. C-type gating mechanisms, best characterized in homotetrameric potassium channels …
Control of breathing by raphe obscurus serotonergic neurons in mice
SD DePuy, R Kanbar, MB Coates… - Journal of …, 2011 - Soc Neuroscience
We used optogenetics to determine the global respiratory effects produced by selectively
stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test …
stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test …
TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons
Phox2b-expressing glutamatergic neurons of the retrotrapezoid nucleus (RTN) display
properties expected of central respiratory chemoreceptors; they are directly activated by …
properties expected of central respiratory chemoreceptors; they are directly activated by …
Nalcn is a “leak” sodium channel that regulates excitability of brainstem chemosensory neurons and breathing
Y Shi, C Abe, BB Holloway, S Shu… - Journal of …, 2016 - Soc Neuroscience
The activity of background potassium and sodium channels determines neuronal excitability,
but physiological roles for “leak” Na+ channels in specific mammalian neurons have not …
but physiological roles for “leak” Na+ channels in specific mammalian neurons have not …
[HTML][HTML] Polynuclear ruthenium amines inhibit K2P channels via a “Finger in the Dam” mechanism
L Pope, M Lolicato, DL Minor - Cell chemical biology, 2020 - cell.com
The trinuclear ruthenium amine ruthenium red (RuR) inhibits diverse ion channels, including
K 2P potassium channels, TRPs, the calcium uniporter, CALHMs, ryanodine receptors, and …
K 2P potassium channels, TRPs, the calcium uniporter, CALHMs, ryanodine receptors, and …
Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2
S Wang, Y Shi, S Shu, PG Guyenet… - Journal of …, 2013 - Soc Neuroscience
Central respiratory chemoreceptors sense changes in CO2/H+ and initiate the adjustments
to ventilation required to preserve brain and tissue pH. The cellular nature of the sensors …
to ventilation required to preserve brain and tissue pH. The cellular nature of the sensors …
Blood pressure regulation by the rostral ventrolateral medulla in conscious rats: effects of hypoxia, hypercapnia, baroreceptor denervation, and anesthesia
Current understanding of the contribution of C1 neurons to blood pressure (BP) regulation
derives predominantly from experiments performed in anesthetized animals or reduced ex …
derives predominantly from experiments performed in anesthetized animals or reduced ex …