Genetic modifiers of cystic fibrosis lung disease severity: whole-genome analysis of 7,840 patients
Rationale: Lung disease is the major cause of morbidity and mortality in persons with cystic
fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR (CF …
fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR (CF …
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
Despite two years of intense global research activity, host genetic factors that predispose to
a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise …
a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise …
Human Molecular Genetics and the long road to treating cystic fibrosis
A Harris - Human Molecular Genetics, 2021 - academic.oup.com
The causative gene in cystic fibrosis (CF) was identified in 1989, 3 years before the
publication of the first issue of Human Molecular Genetics. The cystic fibrosis …
publication of the first issue of Human Molecular Genetics. The cystic fibrosis …
The FOXA1 transcriptional network coordinates key functions of primary human airway epithelial cells
A Paranjapye, MJ Mutolo, JS Ebron… - American Journal of …, 2020 - journals.physiology.org
The differentiated functions of the human airway epithelium are coordinated by a complex
network of transcription factors. These include the pioneer factors Forkhead box A1 and A2 …
network of transcription factors. These include the pioneer factors Forkhead box A1 and A2 …
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
X Li, S Li, B Li, Y Li, S Aman, K Xia, Y Yang… - NPJ Precision …, 2021 - nature.com
E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological
processes, eg, mammogenesis and tumor progression. We have identified a list of p300 …
processes, eg, mammogenesis and tumor progression. We have identified a list of p300 …
Functional genomics analysis of human colon organoids identifies key transcription factors
Organoids are a valuable three-dimensional (3D) model to study the differentiated functions
of the human intestinal epithelium. They are a particularly powerful tool to measure epithelial …
of the human intestinal epithelium. They are a particularly powerful tool to measure epithelial …
The roles of ETS transcription factors in liver fibrosis
LY Zhang, Y Tan, XJ Luo, JF Wu, YR Ni - Human Cell, 2023 - Springer
E26 transformation specific or E twenty-six (ETS) protein family consists of 28 transcription
factors, five of which, named ETS1/2, PU. 1, ERG and EHF, are known to involve in the …
factors, five of which, named ETS1/2, PU. 1, ERG and EHF, are known to involve in the …
[HTML][HTML] Krüppel-Like Factor 5 regulates CFTR expression through repression by maintaining chromatin architecture coupled with direct enhancer activation
Single cell RNA-sequencing has accurately identified cell types within the human airway
that express the Cystic Fibrosis Transmembrane Conductance regulator (CFTR) gene. Low …
that express the Cystic Fibrosis Transmembrane Conductance regulator (CFTR) gene. Low …
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis
R Nightingale, CM Reehorst, N Vukelic… - Developmental Cell, 2024 - cell.com
The transcription factor EHF is highly expressed in the lactating mammary gland, but its role
in mammary development and tumorigenesis is not fully understood. Utilizing a mouse …
in mammary development and tumorigenesis is not fully understood. Utilizing a mouse …
Genomic, transcriptomic, and protein landscape profile of CFTR and cystic fibrosis
M Sanders, JMJ Lawlor, X Li, JN Schuen, SL Millard… - Human genetics, 2021 - Springer
Cystic Fibrosis (CF) is caused most often by removal of amino acid 508 (Phe508del,
deltaF508) within CFTR, yet dozens of additional CFTR variants are known to give rise to CF …
deltaF508) within CFTR, yet dozens of additional CFTR variants are known to give rise to CF …