Natural polymers have been extensively explored as the vehicles for encapsulation and
delivery of drugs and other bioactive molecules, which have attracted tremendous attention …

Most of the administered anti-cancer drugs are hydrophobic in nature and are known to
have poor water solubility, short residence time, rapid clearance from the body and systemic …

Due to their autosynchronous roles in shaping the anti-tumor immune response, complex
immune regulatory networks acting both locally within the tumor microenvironment as well …

Systemic administration of immune checkpoint blockade (ICB) monoclonal antibodies
(mAbs) can unleash antitumor functions of T cells but is associated with variable response …

Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide
(PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of …

Chemotherapy is commonly associated with limited effectiveness and unwanted side effects
in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells …

In order to cure and treat health-related disorders, therapeutic substance must reach its
target site with a constant concentration over a long period of time. As oral administration is …

Combined near-infrared (NIR) fluorescence and photoacoustic imaging techniques present
promising capabilities for noninvasive visualization of biological structures. Development of …

Enhancing therapeutic efficacy of drugs from reactive oxygen species (ROS) and glutathione
(GSH)-responsive matrix and minimizing toxic effects on normal cells remains a challenge in …

As an effective anti-HIV drug, cabotegravir (CAB) is currently administered via oral and
injection routes, leading to several drawbacks, such as poor oral bioavailability and …