The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

Maternal RNA degradation is critical for embryogenesis and is tightly controlled by maternal
RNA-binding proteins. Fragile X mental-retardation protein (FMR1) binds target mRNAs to …

In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …

CRISPR-Cas9 technology is routinely applied for targeted mutagenesis in model organisms
and cell lines. Recent studies indicate that the prokaryotic CRISPR-Cas9 system is affected …

The onset of metazoan development requires that two terminally differentiated germ cells, a
sperm and an oocyte, become reprogrammed to the totipotent embryo, which can …

In many organisms, early embryonic development is driven by maternally provided factors
until the controlled onset of transcription during zygotic genome activation. The regulation of …

Since their discovery, the study of maternal mRNA s has led to the identification of
mechanisms underlying their spatiotemporal regulation within the context of oogenesis and …

At zygotic genome activation (ZGA), changes in chromatin structure are associated with new
transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear …