The success story of hemophilia care first began in the 1970s, when the availability of
plasma-derived concentrates of coagulation factor VIII (FVIII) and factor IX (FIX) provided …

While hemostasis is the physiological process that prevents blood loss after vessel injury,
thrombosis is often portrayed as a pathologic event involving blood coagulation and platelet …

The management of perioperative bleeding involves multiple assessments and strategies to
ensure appropriate patient care. Initially, it is important to identify those patients with an …

The deficiency of fibrinogen, prothrombin, factor V (FV), FVII, FVIII, FIX, FX, FXI, and FXIII,
called rare coagulation disorders (RCDs), may result in coagulopathies leading to …

Factor XI (FXI) deficiency (hemophilia C or Rosenthal disease) was first described in the
1950s by Rosenthal and colleagues 1 in four generations of a family experiencing bleeding …

Congenital fibrinogen disorders (CFDs) are a heterogeneous group of rare inherited
abnormalities of blood coagulation 1. CFDs result from monoallelic or biallelic mutations in …

Mild haemophilia is defined by factor levels between 0.05 and 0.40 IU/mL and is
characterised by traumatic bleeds. Major issues associated with mild haemophilia are that it …

Activated factor VII (FVIIa), the first protease of clotting, expresses its physiological
procoagulant potential only after complexing with tissue factor (TF) exposed to blood. Deep …

Congenital fibrinogen disorders are rare diseases affecting either the quantity
(afibrinogenemia and hypofibrinogenemia) or the quality (dysfibrinogenemia) or both …

The neonatal hemostatic system is strikingly different from that of adults. Among other
differences, neonates exhibit hyporeactive platelets and decreased levels of coagulation …