Stem cell cultivation in bioreactors
Cell-based therapies have generated great interest in the scientific and medical
communities, and stem cells in particular are very appealing for regenerative medicine, drug …
communities, and stem cells in particular are very appealing for regenerative medicine, drug …
Stem cell bioprocessing: fundamentals and principles
MR Placzek, IM Chung, HM Macedo… - Journal of the …, 2009 - royalsocietypublishing.org
In recent years, the potential of stem cell research for tissue engineering-based therapies
and regenerative medicine clinical applications has become well established. In 2006 …
and regenerative medicine clinical applications has become well established. In 2006 …
[图书][B] Biomedical engineering handbook 2
JD Bronzino - 2000 - books.google.com
As we enter the new millennium, the prospects for the field of Biomedical Engineering are
bright. Individuals interested in pursuing careers in this field continue to increase and the …
bright. Individuals interested in pursuing careers in this field continue to increase and the …
In vitro maintenance of highly purified, transplantable hematopoietic stem cells
KA Moore, H Ema, IR Lemischka - Blood, The Journal of the …, 1997 - ashpublications.org
The cellular and molecular mechanisms that regulate the most primitive hematopoietic stem
cell are not well understood. We have undertaken a systematic dissection of the complex …
cell are not well understood. We have undertaken a systematic dissection of the complex …
Augmentation of umbilical cord blood (UCB) transplantation with ex vivo–expanded UCB cells: results of a phase 1 trial using the AastromReplicell System
J Jaroscak, K Goltry, A Smith, B Waters-Pick, PL Martin… - Blood, 2003 - ashpublications.org
Allogeneic stem cell transplantation with umbilical cord blood (UCB) cells is limited by the
cell dose a single unit provides recipients. Ex vivo expansion is one strategy to increase the …
cell dose a single unit provides recipients. Ex vivo expansion is one strategy to increase the …
Differential cytokine effects on primitive (CD34+ CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.
AL Petzer, PW Zandstra, JM Piret… - The Journal of …, 1996 - rupress.org
A high proportion of the CD34+ CD38-cells in normal human marrow are defined as long-
term culture-initiating cells (LTC-IC) because they can proliferate and differentiate when co …
term culture-initiating cells (LTC-IC) because they can proliferate and differentiate when co …
Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.
AL Petzer, DE Hogge, PM Landsdorp… - Proceedings of the …, 1996 - National Acad Sciences
A major goal of experimental and clinical hematology is the identification of mechanisms
and conditions that support the expansion of transplantable hematopoietic stem cells. In …
and conditions that support the expansion of transplantable hematopoietic stem cells. In …
Toward modeling the bone marrow niche using scaffold-based 3D culture systems
N Di Maggio, E Piccinini, M Jaworski, A Trumpp… - Biomaterials, 2011 - Elsevier
In the bone marrow, specialized microenvironments, called niches, regulate hematopoietic
stem cell (HSC) maintenance and function through a complex crosstalk between different …
stem cell (HSC) maintenance and function through a complex crosstalk between different …
Expansion of human cord blood CD34+CD38−cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) …
C Dorrell, OI Gan, DS Pereira… - Blood, The Journal of …, 2000 - ashpublications.org
Current procedures for the genetic manipulation of hematopoietic stem cells are relatively
inefficient due, in part, to a poor understanding of the conditions for ex vivo maintenance or …
inefficient due, in part, to a poor understanding of the conditions for ex vivo maintenance or …
Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human …
DE Hogge, PM Lansdorp, D Reid, B Gerhard, CJ Eaves - 1996 - ashpublications.org
To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC)
assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for …
assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for …