Importance Standard therapy for locally advanced rectal cancer includes concurrent
chemoradiotherapy followed by surgery and adjuvant chemotherapy (CRT plus A). An …

Multimodal treatment strategies for patients with rectal cancer are increasingly including the
possibility of organ preservation, through nonoperative management or local excision …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ
preservation in patients with locally advanced rectal cancer treated with total neoadjuvant …

Importance Total neoadjuvant therapy has been increasingly adopted for multimodal rectal
cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy …

PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is
not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally …

Background Accurate prediction of tumour response to neoadjuvant chemoradiotherapy
enables personalised perioperative therapy for locally advanced rectal cancer. We aimed to …

Background Organ preservation after reaching clinical complete response on neoadjuvant
therapy is gaining interest for rectal cancers, although the role of radiation dose escalation is …

Background Systemic relapses remain a major problem in locally advanced rectal cancer.
Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal …

Background Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal
cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant …