S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …

Meiosis is a specialized style of cell division conserved in eukaryotes, particularly designed
for the production of gametes. A huge number of studies to date have demonstrated how …

Phosphate (Pi) is a macronutrient, and Pi homeostasis is essential for life. Pi homeostasis
has been intensively studied; however, many questions remain, even at the cellular level …

Meiosis is the developmental program that generates gametes. To produce healthy
gametes, meiotic recombination creates reciprocal exchanges between each pair of …

Replication forks restarted by homologous recombination are error prone and replicate both
strands semi-conservatively using Pol δ. Here, we use polymerase usage sequencing to …

In human cells and yeast, an intact" hydrophobic patch" substrate docking site is needed for
mitotic cyclin centrosomal localization. A hydrophobic patch mutant (HPM) of the fission …

Protein kinases are important enzymes involved in the regulation of various cellular
processes. To function properly, each protein kinase phosphorylates only a limited number …

Background Structural maintenance of chromosomes (SMC) complexes are central
organizers of chromatin architecture throughout the cell cycle. The SMC family member …

The length of the mitotic spindle scales with cell size in a wide range of organisms during
embryonic development. Interestingly, in C. elegans embryos, this goes along with temporal …

ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell
polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 …