Immunosenescence: a critical factor associated with organ injury after sepsis

X Lu, YM Yang, YQ Lu - Frontiers in Immunology, 2022 - frontiersin.org
Progressive immune dysfunction associated with aging is known as immunosenescence.
The age-related deterioration of immune function is accompanied by chronic inflammation …

Aging-related mechanisms contribute to corticosteroid insensitivity in elderly asthma

ML Ford, A Ruwanpathirana, BW Lewis… - International journal of …, 2023 - mdpi.com
Asthma in elderly populations is an increasing health problem that is accompanied by
diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs …

UBR5 metabolically reprograms nasopharyngeal carcinoma cells to promote glycolysis and M2 polarization via SPLUNC1 signaling

H Liu, Y Li, L Tang, X Sun, W Xie, T Xiao, W Gu… - NPJ Precision …, 2024 - nature.com
Nasopharyngeal carcinoma (NPC) is the most common cancer originating in nasopharynx.
Metabolic reprogramming plays a critical role in tumor progression. Exploring mechanisms …

Transcriptomic hallmarks of mortality reveal universal and specific mechanisms of aging, chronic disease, and rejuvenation

A Tyshkovskiy, D Kholdina, K Ying, M Davitadze… - bioRxiv, 2024 - biorxiv.org
Health is strongly affected by aging and lifespan-modulating interventions, but the molecular
mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq …

SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells

L Tang, L Peng, H Liu, T Xiao, W Gu, H Yang, H Wang… - Medical Oncology, 2022 - Springer
Nasopharyngeal carcinoma (NPC) is one of the aggressive malignant tumors with high
mortality, and the proliferation of myeloid-derived suppressor cells (MDSCs) could promote …

[HTML][HTML] Similarities and differences in kinetic characteristics of airways inflammation, formation of inducible bronchial-associated lymphoid tissue and remodeling …

T Fu, J Liu, W Wang, Y Li, Y Wang, L Cui, M Liu… - Experimental …, 2023 - Elsevier
Elderly asthmatics have higher morbidity and mortality compared with those of youngers. It
has been shown that there are also some differences in clinic phenomena between young …

Homology Modeling and Molecular Docking of the Antibacterial Protein SPLUNC1/BPIFA1

S Firdous, A Javaid, A Eimen - Riphah Journal of Allied …, 2022 - journals.riphah.edu.pk
Background: Short palate and nasal epithelial clone 1 (SPLUNC1), also known as the
bacterial permeability family member a1 (BPIFA1), is encoded by the lung-specific x gene …