Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …

Caspase-1 is a critical mediator of the inflammatory process by activating various pro-
inflammatory cytokines such as pro-IL-1β, IL-18 and IL-33. Uncontrolled activation of …

The hydrogen-bonding interactions of cysteine, which can serve as a hydrogen-bond donor
and/or acceptor, play a central role in cysteine's diverse functional roles in proteins. They …

Herein is described an efficient and chemoselective method for the synthesis of diversely
substituted secondary amines in yields up to 98%. Direct mono‐N‐alkylation of primary …

Direct access to amines from biomass‐based phenols via deoxygenative transformation
remains greatly challenging in organic synthesis. Herein, we present a palladium‐catalyzed …

Caspases are proteolytic enzymes mainly involved in the induction and execution phases of
apoptosis. This type of programmed cell death is an essential regulatory process required to …

New peptidic templates constrained into a β-strand geometry by linking acetylene and azide
containing P1 and P3 residues of a tripeptide by Huisgen cycloaddition are presented. The …

We report herein, design and synthesis of vinylaminophosphonates, a novel class of
compounds as possible cysteine protease inhibitors. The synthesis of …

The 26S proteasome and calpain are linked to a number of important human diseases.
Here, we report a series of analogues of the prototypical tripeptide aldehyde inhibitor …

Caspases play a central role in apoptosis, differentiation, and proliferation, and represent
important therapeutic targets for treating cancer and inflammatory disorders. Toward the …