The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer
L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …
Ginkgo biloba in the management of the COVID‐19 severity
The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is linked
with inflammatory disorders and the development of oxidative stress in extreme cases …
with inflammatory disorders and the development of oxidative stress in extreme cases …
Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors
G Yan, D Li, Y Lin, Z Fu, H Qi, X Liu, J Zhang, S Si… - Cell & Bioscience, 2021 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly
transmissible and has caused a pandemic named coronavirus disease 2019 (COVID-19) …
transmissible and has caused a pandemic named coronavirus disease 2019 (COVID-19) …
Ginkgo biloba and long COVID: in vivo and in vitro models for the evaluation of nanotherapeutic efficacy
T Akanchise, A Angelova - Pharmaceutics, 2023 - mdpi.com
Coronavirus infections are neuroinvasive and can provoke injury to the central nervous
system (CNS) and long-term illness consequences. They may be associated with …
system (CNS) and long-term illness consequences. They may be associated with …
[HTML][HTML] An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2
F Yan, F Gao - Computational and structural biotechnology journal, 2021 - Elsevier
There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
Marine natural products as leads against SARS-CoV-2 infection
BK Chhetri, PR Tedbury… - Journal of natural …, 2022 - ACS Publications
Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths …
(SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths …
Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro
R Du, L Cooper, Z Chen, H Lee, L Rong, Q Cui - Antiviral research, 2021 - Elsevier
The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To
date, there are limited therapeutic options available to fight this disease. Here we examined …
date, there are limited therapeutic options available to fight this disease. Here we examined …
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization
V Di Sarno, G Lauro, S Musella, T Ciaglia… - European Journal of …, 2021 - Elsevier
COVID-19 pandemic, starting from the latest 2019, and caused by SARS-CoV-2 pathogen,
led to the hardest health-socio-economic disaster in the last century. Despite the …
led to the hardest health-socio-economic disaster in the last century. Despite the …