The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review

X Li, Y Song - European Journal of Medicinal Chemistry, 2023 - Elsevier
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer

L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

Ginkgo biloba in the management of the COVID‐19 severity

HM Al‐kuraishy, AI Al‐Gareeb, A Kaushik… - Archiv der …, 2022 - Wiley Online Library
The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is linked
with inflammatory disorders and the development of oxidative stress in extreme cases …

Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors

G Yan, D Li, Y Lin, Z Fu, H Qi, X Liu, J Zhang, S Si… - Cell & Bioscience, 2021 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly
transmissible and has caused a pandemic named coronavirus disease 2019 (COVID-19) …

Ginkgo biloba and long COVID: in vivo and in vitro models for the evaluation of nanotherapeutic efficacy

T Akanchise, A Angelova - Pharmaceutics, 2023 - mdpi.com
Coronavirus infections are neuroinvasive and can provoke injury to the central nervous
system (CNS) and long-term illness consequences. They may be associated with …

[HTML][HTML] An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2

F Yan, F Gao - Computational and structural biotechnology journal, 2021 - Elsevier
There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …

Marine natural products as leads against SARS-CoV-2 infection

BK Chhetri, PR Tedbury… - Journal of natural …, 2022 - ACS Publications
Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths …

Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro

R Du, L Cooper, Z Chen, H Lee, L Rong, Q Cui - Antiviral research, 2021 - Elsevier
The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To
date, there are limited therapeutic options available to fight this disease. Here we examined …

Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

V Di Sarno, G Lauro, S Musella, T Ciaglia… - European Journal of …, 2021 - Elsevier
COVID-19 pandemic, starting from the latest 2019, and caused by SARS-CoV-2 pathogen,
led to the hardest health-socio-economic disaster in the last century. Despite the …